Loading...
Interplay between genetic risk and the parent environment in adolescence and substance use in young adulthood: A TRAILS study
Pasman,Joëlle A Smit,Koen Vollebergh,Wilma A M Nolte,Ilja M Hartman,Catharina A Abdellaoui,Abdel Verweij,Karin J H Maciejewski,Dominique Vink,Jacqueline M
Pasman,Joëlle A
Smit,Koen
Vollebergh,Wilma A M
Nolte,Ilja M
Hartman,Catharina A
Abdellaoui,Abdel
Verweij,Karin J H
Maciejewski,Dominique
Vink,Jacqueline M
Abstract
Many adolescents start using tobacco, alcohol, and cannabis. Genetic vulnerability, parent characteristics in young adolescence, and interaction (GxE) and correlation (rGE) between these factors could contribute to the development of substance use. Using prospective data from the TRacking Adolescent Individuals' Lives Survey (TRAILS; N = 1,645), we model latent parent characteristics in young adolescence to predict young adult substance use. Polygenic scores (PGS) are created based on genome-wide association studies (GWAS) for smoking, alcohol use, and cannabis use. Using structural equation modeling we model the direct, GxE, and rGE effects of parent factors and PGS on young adult smoking, alcohol use, and cannabis initiation. The PGS, parental involvement, parental substance use, and parent-child relationship quality predicted smoking. There was GxE such that the PGS amplified the effect of parental substance use on smoking. There was rGE between all parent factors and the smoking PGS. Alcohol use was not predicted by genetic or parent factors, nor by interplay. Cannabis initiation was predicted by the PGS and parental substance use, but there was no GxE or rGE. Genetic risk and parent factors are important predictors of substance use and show GxE and rGE in smoking. These findings can act as a starting point for identifying people at risk.
Description
Funding Information: TRAILS has been financially supported by various grants from the Netherlands Organization for Scientific Research (NWO), ZonMW, GB-MaGW, the Dutch Ministry of Justice, the European Science Foundation, the European Research Council, BBMRI-NL, and the participating universities. Funding Information: KJHV and AA were supported for this work by the Volksbond Rotterdam.
Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue
Keywords
Young Adult, Humans, Adolescent, Adult, Prospective Studies, Genome-Wide Association Study, Risk Factors, Parents, Substance-Related Disorders/genetics
Citation
Pasman, J A, Smit, K, Vollebergh, W A M, Nolte, I M, Hartman, C A, Abdellaoui, A, Verweij, K J H, Maciejewski, D & Vink, J M 2023, 'Interplay between genetic risk and the parent environment in adolescence and substance use in young adulthood : A TRAILS study', Development and Psychopathology, vol. 35, no. 1, pp. 396-409. https://doi.org/10.1017/S095457942100081X
License
info:eu-repo/semantics/openAccess