Fatigue among short- and long-term thyroid cancer survivors: Results from the population-based PROFILES registry
Husson,O. Nieuwlaat,W.-A. Oranje,W.A. Haak,H.R. van de Poll-Franse,L.V. Mols,F.
Husson,O.
Nieuwlaat,W.-A.
Oranje,W.A.
Haak,H.R.
van de Poll-Franse,L.V.
Mols,F.
Abstract
Background: The aims of this study were (i) to obtain insight into the prevalence of fatigue among short- and long-term thyroid cancer (TC) survivors, by comparing a sample of TC survivors with an age- and sex-matched normative population, and (ii) to investigate which demographic, clinical, and TC-specific health-related quality of life (HRQoL) characteristics were associated with fatigue. Methods: All patients found to have TC between 1990 and 2008, as registered in the Eindhoven Cancer Registry, received a cross-sectional survey on fatigue (Fatigue Assessment Scale), TC-specific HRQoL (THYCA-QoL), and psychological distress (Hospital Anxiety and Depression Scale). The fatigue scores were compared with those of an age- and sex-matched normative population (n=530). Multiple logistic regression analyses were conducted to investigate the independent associations between clinical and demographic characteristics, TC-specific HRQoL, and psychological distress with fatigue. Results: Eighty-six percent (n=306) responded. TC survivors were more often classified as fatigued or very fatigued (short-term <5 years: 43%; long-term 5–10 years: 44%; long-term 10–15 years: 47%; long-term >15 years: 39%) compared to the normative population (25%; p<0.001). Anxiety (odds ratio (OR) 1.15, 95% confidence interval [CI] 1.03–1.28) and depression (OR 1.43 [CI 1.22–1.68]) were associated with fatigue, as was also the case for TC-specific neuromuscular (OR 1.03 [CI 1.01–1.06]), concentration (OR 1.03 [CI 1.01–1.06]), and psychological TC-specific HRQoL (OR 1.06 [CI 1.02–1.10]). Conclusion: Short- and long-term TC survivors report higher levels of fatigue than an age- and sex-matched normative population do. Both TC-specific HRQoL and psychological distress were associated with fatigue.
Description
Date
2013
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Volume Title
Publisher
Research Projects
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Keywords
SDG 3 - Good Health and Well-being
Citation
Husson, O, Nieuwlaat, W-A, Oranje, W A, Haak, H R, van de Poll-Franse, L V & Mols, F 2013, 'Fatigue among short- and long-term thyroid cancer survivors : Results from the population-based PROFILES registry', Thyroid, vol. 23, no. 10, pp. 1247-1255. https://doi.org/10.1089/thy.2013.0015
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info:eu-repo/semantics/closedAccess