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Self-perceived cognitive functioning and quality of life among cancer survivors: Results from the PROFILES registry
Oerlemans,Simone Schagen,Sanne B. van den Hurk,Corina J. Husson,Olga Schoormans,Dounya van de Poll-Franse,Lonneke V.
Oerlemans,Simone
Schagen,Sanne B.
van den Hurk,Corina J.
Husson,Olga
Schoormans,Dounya
van de Poll-Franse,Lonneke V.
Abstract
Purpose: The aim was to investigate the level of self-perceived cognitive functioning and its associated factors among a large population-based cohort of cancer survivors and their matched controls. Methods: Data were obtained from population-based PROFILES registry cohorts, including colon, rectum, prostate or thyroid cancer, Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia, multiple myeloma (MM), melanoma, or basal cell carcinoma (BCC)/squamous cell carcinoma (SCC). All patients completed the EORTC QLQ-C30 from which self-perceived cognitive functioning, fatigue, functioning, and global health status/quality of life (GHS/QoL) were used. The PROFILES registry data were linked with the Netherlands Cancer Registry to obtain sociodemographic and clinical data. Results: Six thousand seven hundred eighty-six survivors were included (response rate=76%). Survivors, except for melanoma and BCC/SCC, reported on average lower self-perceived cognitive functioning scores compared to their matched controls (all p’s<0.01). Largest differences with the norm were observed in thyroid cancer, HL, NHL and MM, and younger survivors (<50 years). Survivors with lower emotional functioning and more fatigue were more likely to report impaired self-perceived cognitive functioning. Conclusion: S elf-perceived impaired cognitive functioning is prevalent among a wide range of cancer survivors, especially among survivors <50 years. Approaches targeting cognitive problems including attention for co-occurring symptoms such as fatigue and emotional impairments are needed to improve care for these patients. Implications for Cancer Survivors: Cancer survivors and clinicians should be aware that impaired self-perceived cognitive functioning is a frequently reported consequence of cancer and its treatment among survivors of various cancer types. Clinicians can redirect survivors to a relevant healthcare provider or program to target cognitive problems.
Description
Funding Information: The PROFILES registry was funded by an Investment Grant (#480-08-009) of the Netherlands Organization for Scientific Research (The Hague, The Netherlands).
Date
2022
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Research Projects
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Keywords
Cancer survivors, Cognitive functioning, Quality of life, Fatigue, Anxiety, Normative population, SDG 3 - Good Health and Well-being
Citation
Oerlemans, S, Schagen, S B, van den Hurk, C J, Husson, O, Schoormans, D & van de Poll-Franse, L V 2022, 'Self-perceived cognitive functioning and quality of life among cancer survivors : Results from the PROFILES registry', Journal of Cancer Survivorship, vol. 16, no. 2, pp. 303-313. https://doi.org/10.1007/s11764-021-01023-9