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Associations of the dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations with patient-reported outcomes in colorectal cancer survivors 2–10 years post-diagnosis: A cross-sectional analysis
Kenkhuis,M.L. van der Linden,B.W.A. Breedveld-Peters,J.J.L. Koole,J.L. van Roekel,E.H. Breukink,S.O. Mols,F. Weijenberg,M.P. Bours,M.J.L.
Kenkhuis,M.L.
van der Linden,B.W.A.
Breedveld-Peters,J.J.L.
Koole,J.L.
van Roekel,E.H.
Breukink,S.O.
Mols,F.
Weijenberg,M.P.
Bours,M.J.L.
Abstract
The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Adhering to these recommendations may have beneficial effects on patient-reported outcomes after a cancer diagnosis, but evidence is scarce. We aimed to assess associations of the individual dietary WCRF/AICR recommendations regarding fruit and vegetables, fibre, fast foods, red and processed meat, sugar-sweetened drinks and alcohol consumption with patient-reported outcomes in colorectal cancer (CRC) survivors. Cross-sectional data of 150 stage I–III CRC survivors, 2–10 years post-diagnosis, were used. Dietary intake was measured by 7-d dietary records. Validated questionnaires were used to measure health-related quality of life (HRQoL), fatigue and neuropathy. Confounder-adjusted linear regression models were used to analyse associations of each WCRF/AICR dietary recommendation with patient-reported outcomes. Higher vegetable intake (per 50 g) was associated with better global QoL (β 2·6; 95 % CI 0·6, 4·7), better physical functioning (3·3; 1·2, 5·5) and lower levels of fatigue (−4·5; −7·6, −1·4). Higher fruit and vegetables intake (per 100 g) was associated with better physical functioning (3·2; 0·8, 5·5) and higher intake of energy-dense food (per 100 kJ/100 g) with worse physical functioning (−4·2; −7·1, −1·2). No associations of dietary recommendations with neuropathy were found. These findings suggest that adhering to specific dietary WCRF/AICR recommendations is associated with better HRQoL and less fatigue in CRC survivors. Although the recommendations regarding healthy dietary habits may be beneficial for the well-being of CRC survivors, longitudinal research is warranted to gain insight into the direction of associations.
Description
Funding Information: M. K. is funded by the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (grant no. 2017/1619). J. J. L. B.-P. was funded and J. L. K. is currently funded by Kankeronderzoekfonds Limburg as part of Health Foundation Limburg (grant no. 00005739). E. H. van R. is funded by the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (grant no. 2016/1620). The EnCoRe study was also funded by grants from the Stichting Alpe d’HuZes within the research programme ‘Leven met kanker’ of the Dutch Cancer Society (grant no. UM-2010-4867 and UM-2012-5653).
Date
2021-05-28
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Research Projects
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Keywords
BODY-MASS INDEX, CHEMOTHERAPY, COLON-CANCER, Colorectal cancer survivorship, Diet, Fatigue, HEALTH, Health-related quality of life, INDUCED PERIPHERAL NEUROPATHY, Lifestyle recommendations, MEDITERRANEAN DIET, Neuropathy, PHYSICAL-ACTIVITY, QUALITY-OF-LIFE, STYLE FACTORS, VEGETABLE INTAKE, SDG 3 - Good Health and Well-being
Citation
Kenkhuis, M L, van der Linden, B W A, Breedveld-Peters, J J L, Koole, J L, van Roekel, E H, Breukink, S O, Mols, F, Weijenberg, M P & Bours, M J L 2021, 'Associations of the dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations with patient-reported outcomes in colorectal cancer survivors 2–10 years post-diagnosis : A cross-sectional analysis', British Journal of Nutrition, vol. 125, no. 10, pp. 1188-1200. https://doi.org/10.1017/S0007114520003487
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info:eu-repo/semantics/openAccess