Loading...
Symptoms of pre-treatment anxiety are associated with the development of chronic peripheral neuropathy among colorectal cancer patients
Bonhof,C.S. van de Graaf,D.L. Wasowicz,D.K. Vreugdenhil,G. Mols,F.
Bonhof,C.S.
van de Graaf,D.L.
Wasowicz,D.K.
Vreugdenhil,G.
Mols,F.
Abstract
Purpose Identifying potentially modifiable predictors of chronic (chemotherapy-induced) peripheral neuropathy (PN) is important, especially in light of the limited treatment options. We aimed to examine pre-treatment anxiety and depressive symptoms as predictors of chronic PN symptom severity in colorectal cancer (CRC) patients up to two years after diagnosis. Methods Newly diagnosed CRC patients from four Dutch hospitals were eligible for participation. Patients (N=336) completed a questionnaire on anxiety and depressive symptoms (HADS) and sensory (SPN) and motor peripheral neuropathy (MPN) (EORTC QLQ-CIPN20) before initial treatment (baseline) and one and two years after diagnosis. Patients were included in the analyses if they either developed some level of SPN or MPN symptoms, or experienced a worsening of pre-treatment SPN or MPN symptoms. Results At one-year follow-up, 115 patients (34%) reported SPN symptoms and 134 patients (40%) reported MPN symptoms. Of these patients, SPN and MPN symptoms had not returned to baseline level at two-year follow-up in, respectively, 51% and 54% of patients. In multivariable regression analyses, neither pre-treatment anxiety symptoms nor pre-treatment depressive symptoms were associated with SPN or MPN symptom severity at one-year follow-up. At two-year follow-up, pre-treatment anxiety symptoms (β=0.44, p=0.01), but not depressive symptoms, were associated with SPN symptom severity. Conclusions Pre-treatment anxiety symptoms, but not depressive symptoms, were associated with SPN symptom severity two years after diagnosis. Future studies are needed that assess whether interventions targeted to reduce anxiety before and during treatment can reduce chronic PN severity or even prevent the persistence of PN.
Description
The present research was supported by the Center of Research on Psychological disorders and Somatic diseases (CoRPS), Tilburg University, the Netherlands; the Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands; and an Investment Subsidy Large (2016/04981/ZONMW-91101002) of the Netherlands Organization for Scientific Research (The Hague, the Netherlands).
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue
Keywords
Anxiety/etiology, Colorectal Neoplasms/complications, Humans, Peripheral Nervous System Diseases/chemically induced, Quality of Life, Surveys and Questionnaires, SDG 3 - Good Health and Well-being
Citation
Bonhof, C S, van de Graaf, D L, Wasowicz, D K, Vreugdenhil, G & Mols, F 2022, 'Symptoms of pre-treatment anxiety are associated with the development of chronic peripheral neuropathy among colorectal cancer patients', Supportive Care in Cancer, vol. 30, no. 6, pp. 5421-5429. https://doi.org/10.1007/s00520-022-06971-1