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Variation in the serotonin transporter polymorphism (5-HTTLPR) and inertia of negative and positive emotions in daily life
van Roekel,G.H. Verhagen,Maaike Engels,Rutger C M E Kuppens,Peter
van Roekel,G.H.
Verhagen,Maaike
Engels,Rutger C M E
Kuppens,Peter
Abstract
An important element of understanding the genotype-phenotype link in psychiatric disorders lies in identifying the psychological mechanisms through which genetic variation impacts mental health. Here we examined whether emotional inertia, the tendency for a person's emotions to carry over from 1 moment to the next and a prospective predictor of the development of depression, is associated with a known genetic risk factor for emotional dysregulation, a polymorphism in the serotonin transporter gene (5-HTTLPR). Two hundred thirty-six adolescents recorded their positive and negative emotions in daily life 9 times a day for 6 consecutive days using smartphones, completed a depression questionnaire, and were genotyped for the 5-HTTLPR polymorphism. Carriers of the short 5-HTTLPR were characterized by higher inertia for negative emotions, even after controlling for depressive symptoms. These findings suggest a possible psychological pathway how the serotonin transporter gene contributes to risk for depression. (PsycINFO Database Record
Description
(c) 2017 APA, all rights reserved).
Date
2018
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Publisher
Research Projects
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Keywords
emotional inertia, 5-HTTLPR, depression, experience sampling method, endophenotype, MAJOR DEPRESSIVE DISORDER, GENE-ENVIRONMENT INTERACTION, INDIVIDUAL-DIFFERENCES, ADOLESCENT DEPRESSION, METAANALYSIS, REACTIVITY, ASSOCIATION, EXPERIENCE, INSTABILITY, ANXIETY
Citation
van Roekel, G H, Verhagen, M, Engels, R C M E & Kuppens, P 2018, 'Variation in the serotonin transporter polymorphism (5-HTTLPR) and inertia of negative and positive emotions in daily life', Emotion, vol. 18, no. 2, pp. 229-236. https://doi.org/10.1037/emo0000336