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Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy
Van den Bergh,Bea R H van den Heuvel,Marion I Lahti,Marius Braeken,Marijke de Rooij,Susanne R Entringer,Sonja Hoyer,Dirk Roseboom,Tessa Räikkönen,Katri King,Suzanne
Van den Bergh,Bea R H
van den Heuvel,Marion I
Lahti,Marius
Braeken,Marijke
de Rooij,Susanne R
Entringer,Sonja
Hoyer,Dirk
Roseboom,Tessa
Räikkönen,Katri
King,Suzanne
Abstract
Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Offspring of both sexes are susceptible to prenatal stress but effects differ. There is not any specific vulnerable period of gestation; prenatal stress effects vary for different gestational ages possibly depending on the developmental stage of specific brain areas and circuits, stress system and immune system. Biological correlates in the prenatally stressed offspring are: aberrations in neurodevelopment, neurocognitive function, cerebral processing, functional and structural brain connectivity involving amygdalae and (pre)frontal cortex, changes in hypothalamo-pituitary-adrenal (HPA)-axis and autonomous nervous system.
Description
Funding Information: Tessa Roseboom, Matthias Schwab and Bea van den Bergh, received support from EU FP7/Health.2011.2.22-2, GA 2798219 . Marius Lahti and Katri Räikkönen received funding from Academy of Finland and University of Helsinki . Katri Räikkönen also received funding from Signe and Ane Gyllenberg Foundation . Suzanne King received funding from the Canadian Institutes of Health Research (CIHR) for Project Ice Storm ( MOP-111177 ), the Iowa Flood Study ( MOP-93660 ), and the QF2011 Queensland Flood Study ( MOP-1150067 ).
Date
2020
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Keywords
Anxiety, Attention deficit hyperactivity disorder (ADHD), Autism, Autonomic nervous system, Brain network connectivity, Cortisol, Depression, Disaster exposure, EEG, Epigenetics, Event related potential (ERP), Fetal programming, Functional magnetic resonance imaging (fMRI), Gut microbiome, HPA-axis, Heart rate variability, Life events, Maternal psychological distress, Objective stress, Pregnancy-specific anxiety, Psychiatric disorders, Schizophrenia, Telomere biology
Citation
Van den Bergh, B R H, van den Heuvel, M I, Lahti, M, Braeken, M, de Rooij, S R, Entringer, S, Hoyer, D, Roseboom, T, Räikkönen, K, King, S & Schwab, M 2020, 'Prenatal developmental origins of behavior and mental health : The influence of maternal stress in pregnancy', Neuroscience and Biobehavioral Reviews, vol. 117, pp. 26-64. https://doi.org/10.1016/j.neubiorev.2017.07.003
License
info:eu-repo/semantics/openAccess