Self-reported health-related quality of life predicts 5-year mortality and hospital readmissions in patients with ischaemic heart disease
Hansen,Tina Birgitte Thygesen,Lau Caspar Zwisler,Ann Dorthe Helmark,Lotte Hoogwegt,Madelein Versteeg,Henneke Höfer,Stefan Oldridge,Neil
Hansen,Tina Birgitte
Thygesen,Lau Caspar
Zwisler,Ann Dorthe
Helmark,Lotte
Hoogwegt,Madelein
Versteeg,Henneke
Höfer,Stefan
Oldridge,Neil
Abstract
Background Patient health-related quality of life (HRQL) is an important health outcome with lower HRQL associated with adverse events in patients with ischaemic heart disease (IHD).Design Baseline health-related quality of life was investigated as a predictor of 5-year all-cause mortality and cardiac readmissions in Danish patients with IHD. Methods The international HeartQoL Project survey was designed to develop a core HRQL questionnaire for patients with IHD. Baseline scores on each of the 14 items ultimately included in the HeartQoL questionnaire were linked to Danish national health registries and hazard ratios for mortality and readmissions were estimated using Cox regression models.Results Among 938 eligible Danish patients with IHD, 662 (70.6%) participated in the international HeartQoL Project. During the 5-year follow-up, 83 patients died and 196 patients were readmitted. Adjusted analyses showed a significant linear association between all-cause mortality and both lower global HRQL (HR = 1.67, 95% CI: 1.26–2.23; p < 0.001) and physical scores (HR = 1.71, 1.33–2.21; p < 0.001) and between readmission and both lower global (HR = 1.73, 1.41–2.12; p < 0.001) and physical scores (HR = 1.63, 1.35–1.96; p < 0.001). A significant, but non-linear, effect was found for emotional HRQL score on outcomes. Conclusion This study shows a significant and linear relationship between lower global and physical HRQL scores in patients with IHD and 5-year all-cause mortality and cardiac readmission.
Description
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue
Keywords
SDG 3 - Good Health and Well-being
Citation
Hansen, T B, Thygesen, L C, Zwisler, A D, Helmark, L, Hoogwegt, M, Versteeg, H, Höfer, S & Oldridge, N 2015, 'Self-reported health-related quality of life predicts 5-year mortality and hospital readmissions in patients with ischaemic heart disease', European Journal of Preventive Cardiology, vol. 22, no. 7, pp. 882-889. https://doi.org/10.1177/2047487314535682
License
info:eu-repo/semantics/closedAccess