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The course of peripheral neuropathy and its association with health-related quality of life among colorectal cancer patients
Bonhof,C.S. van de Poll-Franse,L.V. Wasowicz,D.K. Beerepoot,L.V. Vreugdenhil,G. Mols,F.
Bonhof,C.S.
van de Poll-Franse,L.V.
Wasowicz,D.K.
Beerepoot,L.V.
Vreugdenhil,G.
Mols,F.
Abstract
Purpose: To gain more insight into the course of chemotherapy-induced peripheral neuropathy (CIPN) and its impact on health-related quality of life (HRQoL) in a population-based sample of colorectal cancer (CRC) patients up to 2 years after diagnosis. Methods: All newly diagnosed CRC patients from four hospitals in the Netherlands were eligible for participation in an ongoing prospective cohort study. Patients (n = 340) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30) before initial treatment (baseline) and 1 and 2 years after diagnosis. Results: Among chemotherapy-treated patients (n = 105), a high sensory peripheral neuropathy (SPN) level was reported by 57% of patients at 1 year, and 47% at 2-year follow-up, whereas a high motor peripheral neuropathy (MPN) level was reported by 47% and 28%, at years 1 and 2, respectively. Linear mixed model analyses showed that SPN and MPN symptoms significantly increased from baseline to 1-year follow-up and did not return to baseline level after 2 years. Patients with a high SPN or MPN level reported a worse global quality of life and a worse physical, role, emotional, cognitive, and social functioning compared with those with a low SPN or MPN level. Conclusions: Future studies should focus on understanding the mechanisms underlying CIPN so targeted interventions can be developed to reduce the impact of CIPN on patient’s lives. Implications for cancer survivors: Patients need to be informed of both CIPN and the impact on HRQoL.
Description
Funding Information: The present research was supported by the Center of Research on Psychology in Somatic Disorders (CoRPS), Tilburg University, the Netherlands; the Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands; and an Aspasia grant of the Netherlands Organization for Scientific Research (The Hague, The Netherlands). Acknowledgments Novelty and impact
Date
2021
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Keywords
CHEMOTHERAPY, Colorectal cancer, Health-related quality of life, OXALIPLATIN, PROFILES, Peripheral neuropathy, QUESTIONNAIRE, SURVIVORS, SDG 3 - Good Health and Well-being
Citation
Bonhof, C S, van de Poll-Franse, L V, Wasowicz, D K, Beerepoot, L V, Vreugdenhil, G & Mols, F 2021, 'The course of peripheral neuropathy and its association with health-related quality of life among colorectal cancer patients', Journal of Cancer Survivorship, vol. 15, no. 2, pp. 190-200. https://doi.org/10.1007/s11764-020-00923-6
License
info:eu-repo/semantics/openAccess