Trajectories of health‐related quality of life and symptom burden in patients with advanced cancer towards the end of life: Longitudinal results from the eQuiPe study
Versluis,M.A.J. Raijmakers,N.J.H. Baars,A. Van den beuken‐van everdingen,M.H.J. De graeff,A. Hendriks,M.P. De jong,W.K. Kloover,J.S. Kuip,E.J.M. Mandigers,C.M.P.W.
Versluis,M.A.J.
Raijmakers,N.J.H.
Baars,A.
Van den beuken‐van everdingen,M.H.J.
De graeff,A.
Hendriks,M.P.
De jong,W.K.
Kloover,J.S.
Kuip,E.J.M.
Mandigers,C.M.P.W.
Abstract
Background Support for health-related quality of life (HRQOL) is an essential part of cancer care in the final stages of life, yet empirical guidance regarding HRQOL and symptom trajectories is lacking. Aim To assess the change in HRQOL and symptom burden in the last year of life in patients with advanced cancer and its association with health care–related factors, cancer-specific treatment, and comorbidity. Methods A prospective, multicenter, observational study in patients with advanced cancer (eQuiPe). Three monthly questionnaires included European Organization for Research and Treatment of Cancer Quality of Life-C30 and reported continuity of care. Multivariable mixed-effects analysis was used to assess the association between HRQOL and health care–related factors. Results A total of 762 deceased patients were included with a mean age of 66 (SD, 10) years and 52% were male. The most common primary tumors were lung (29%), colorectal (20%), and breast cancer (13%). Mean overall HRQOL decreased in the last 9 months of life, with the greatest decrease in the last 3 months (β –16.2). Fatigue, pain, appetite loss, dyspnea, constipation, and nausea worsened significantly in the last year of life. Multimorbidity (β –7.5) and a better reported continuity of care (β 0.7) were both significantly associated with the trajectory of HRQOL. Conclusion Mean overall HRQOL begins to decline 9 months before death, highlighting the need for early identification and (re)assessment of different symptoms as aspects of HRQOL follow different trajectories. Multimorbidity and reported continuity of care may be associated with the trajectory of HRQOL.
Description
Date
2024
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Volume Title
Publisher
Research Projects
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Keywords
advanced cancer, continuity of care, longitudinal, palliative care, quality of life, SDG 3 - Good Health and Well-being
Citation
Versluis, M A J, Raijmakers, N J H, Baars, A, Van den beuken‐van everdingen, M H J, De graeff, A, Hendriks, M P, De jong, W K, Kloover, J S, Kuip, E J M, Mandigers, C M P W, Sommeijer, D W, Van der linden, Y M & van de Poll‐Franse, L V 2024, 'Trajectories of health‐related quality of life and symptom burden in patients with advanced cancer towards the end of life : Longitudinal results from the eQuiPe study', Cancer, vol. 130, no. 4, pp. 609-617. https://doi.org/10.1002/cncr.35060