Levels of somatic hypermutations in B cell receptors increase during childhood
Schatorjé,E.J. Driessen,G.J. van Hout,R.M.W.M. van der Burg,M. de Vries,E.
Schatorjé,E.J.
Driessen,G.J.
van Hout,R.M.W.M.
van der Burg,M.
de Vries,E.
Abstract
Somatic hypermutation (SHM) is an important step in antigen-driven B cell development creating B lymphocytes expressing high-affinity antibody receptors. It is known that the peripheral B lymphocyte compartments of healthy children and adults differ considerably. However, the development of SHM with age has not been studied in detail previously. Therefore, we used the immunoglobulin (Ig)κ-restriction enzyme hot-spot mutation assay (Igκ-REHMA) to gain an estimation of SHM levels in different age groups in order to relate this to the size of the memory B lymphocyte subpopulations. We show that the level of SHM increases rapidly during the first 2 years of life. This reflects the changes of the memory B cell subpopulations, but also changes in the SHM within memory B cell subsets, probably reflecting an increase of secondary memory B cell responses.
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Date
2014
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Research Projects
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Schatorjé, E J, Driessen, G J, van Hout, R M W M, van der Burg, M & de Vries, E 2014, 'Levels of somatic hypermutations in B cell receptors increase during childhood', Clinical and Experimental Immunology, vol. 178, no. 2, pp. 394-398. https://doi.org/10.1111/cei.12419
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info:eu-repo/semantics/closedAccess