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MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer
Vos,M.C. Hollemans,E. Ezendam,N.P.M. Feijen,H. Boll,D. Pijlman,B. van der Putten,H. Klinkhamer,P. Kuppevelt,T.H. van de Wurff,A.A.
Vos,M.C.
Hollemans,E.
Ezendam,N.P.M.
Feijen,H.
Boll,D.
Pijlman,B.
van der Putten,H.
Klinkhamer,P.
Kuppevelt,T.H.
van de Wurff,A.A.
Abstract
Background To investigate the expression of MMP-14 and CD44 as well as epithelial-to-mesenchymal transition(EMT)-like changes in ovarian cancer and to determine correlations with clinical outcome. Methods In 97 patients with ovarian cancer, MMP-14 and CD44 expression as determined by immunohistochemistry was investigated in relation to EMT-like changes. To determine this, immunohistochemical staining of E-cadherin and vimentin was performed. Results Patients with expression of both MMP-14 and CD44 in their tumors had a poor prognosis despite complete debulking. Serous histology in advanced-stage tumors (FIGO IIB-IV) correlated with CD44 (rho .286, p < 0.01). Also, CD44 correlated with percentage vimentin expression (rho .217, p < 0.05).In logistic regression analysis with complete debulking as the outcome parameter, CD44 expression was found to be significant (OR 3,571 (95 % Confidence Interval 1,112–11,468) p = 0.032), though this was not the case for MMP-14 and EMT parameters. Conclusion The subgroup of patients with double expression of MMP-14 and CD44 had a poor prognosis despite complete debulking. Serous subtype in advanced-stage patients and CD44 expression were found to be correlated with vimentin expression, and CD44 expression was found to be significantly correlated with complete debulking. However, a significant correlation between EMT and clinical parameters was not found.KeywordsMMP-14, CD44, Epithelial-to-mesenchymal transition, Ovarian cancer
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2016-09-02
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SDG 3 - Good Health and Well-being
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Vos, M C, Hollemans, E, Ezendam, N P M, Feijen, H, Boll, D, Pijlman, B, van der Putten, H, Klinkhamer, P, Kuppevelt, T H, van de Wurff, A A & Massuger, L F 2016, 'MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer', Journal of Ovarian Research, vol. 9, no. 1, 53. https://doi.org/10.1186/s13048-016-0262-7