Loading...
Treatment of cognitive deficits in brain tumour patients: Current status and future directions
Coomans,Marijke van der Linden,Sophie Gehring,Karin Taphoorn,Martin J B
Coomans,Marijke
van der Linden,Sophie
Gehring,Karin
Taphoorn,Martin J B
Abstract
Purpose of review: Increased life expectancy in brain tumour patients had led to the need for strategies that preserve and improve cognitive functioning, as many patients suffer from cognitive deficits. The tumour itself, as well as antitumor treatment including surgery, radiotherapy and chemotherapy, supportive treatment and individual patient factors are associated with cognitive problems. Here, we review the recent literature on approaches that preserve and improve cognitive functioning, including pharmacological agents and rehabilitation programs. Recent findings: Minimizing cognitive dysfunction and improving cognitive functioning in brain tumour patients may be achieved both by preserving cognitive functioning during antitumor treatment, including techniques such as awake brain surgery, less invasive radiation therapies such as stereotactic radiotherapy and proton therapy, as well as with interventions including cognitive rehabilitation programmes. Novel rehabilitation programs including computer-based cognitive rehabilitation therapy (CRT) programmes that can be adjusted to the specific patient needs and can be administered at home are promising. Furthermore, personalized/precision medicine approaches to identify patients who are at risk for cognitive decline may facilitate effective treatment strategies in the future. Summary: Cognitive functioning has gained greater awareness in the neuro-oncological community, and methods to preserve and improve cognitive functioning have been explored. Rehabilitation programmes for brain tumour patients should be further developed and referred to in clinical practice.
Description
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue
Keywords
DOUBLE-BLIND, ELOQUENT AREAS, HIGH-GRADE GLIOMA, NEUROCOGNITIVE FUNCTION, PHASE-III, PRIMARY CNS LYMPHOMA, QUALITY-OF-LIFE, RADIOTHERAPY, REHABILITATION, SURGERY, brain tumour, cognitive deficits, rehabilitation, treatment, SDG 3 - Good Health and Well-being
Citation
Coomans, M, van der Linden, S, Gehring, K & Taphoorn, M J B 2019, 'Treatment of cognitive deficits in brain tumour patients : Current status and future directions', Current Opinion in Oncology, vol. 31, no. 6, pp. 540-547. https://doi.org/10.1097/CCO.0000000000000581
License
info:eu-repo/semantics/openAccess