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Association of serum MicroRNA-145-5p levels with microvascular complications of type 1 Diabetes: The EURODIAB prospective complications study
Barutta,Federica Bellini,Stefania Guarrera,Simonetta Matullo,Giuseppe Schalkwijk,Casper Stehouwer,Coen D. Chaturvedi,Nish Soedamah-Muthu,Sabita S. Durazzo,Marilena Gruden,Gabriella
Barutta,Federica
Bellini,Stefania
Guarrera,Simonetta
Matullo,Giuseppe
Schalkwijk,Casper
Stehouwer,Coen D.
Chaturvedi,Nish
Soedamah-Muthu,Sabita S.
Durazzo,Marilena
Gruden,Gabriella
Abstract
Aims To investigate whether serum miR-145-5p levels were associated with micro-macrovascular chronic complications in patients with type 1 diabetes (DM1). Methods A nested case-control study from the EURODIAB Prospective Complications Study was performed. Cases (n = 289) had one or more complications of diabetes, whereas controls (n = 153) did not have any complication. We measured miR-145-5p levels by qPCR and investigated the association with diabetes complications. Results Mean miR-145-5p levels were significantly lower in cases with microangiopathy [2.12 (0.86–4.94)] compared to controls [3.15 (1.21–7.36), P < 0.05] even after adjustment for age, gender, and diabetes duration. In logistic regression analysis, miR-145-5p levels in the lowest tertile were associated with an over three-fold increased odds ratio (OR) of albuminuria [3.22 (1.17–8.81)], independently of both demographic and diabetes-related factors. In addition, mir145-5p levels in the lowest tertile were independently and inversely associated with arterial hypertension [1.96 (1.08–3.56)] and hypertension was the mediator of the relationship between miR-145-5p and albuminuria. Conclusions In this large cohort of DM1 patients, we found an inverse association between miR-145-5p and albuminuria that was mediated by systemic hypertension.
Description
This work was supported by the Cassa di Risparmio di Torino (CRT), the European Foundation for the Study of Diabetes (EFSD), Turin University (ex60%), Italian Ministry for Education, University and Research (Ministero dell'Istruzione, dell'Università e della Ricerca ‐ MIUR) under the program “Dipartimenti di Eccellenza 2018–2022” project D15D18000410001.
Date
2022
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Keywords
Albuminuria, BIOMARKERS, CARDIOVASCULAR-DISEASE, CIRCULATING MICRORNAS, Cardiovascular diseases, Diabetic complications, Diabetic kidney disease, Diabetic nephropathy, EXPRESSION, Hypertension, MARKERS, MECHANISMS, MIRNAS, RETINOPATHY, SMOOTH-MUSCLE-CELLS, TARGETS, TGF-beta 1, Type 1 diabetes, microRNAs, SDG 3 - Good Health and Well-being
Citation
Barutta, F, Bellini, S, Guarrera, S, Matullo, G, Schalkwijk, C, Stehouwer, C D, Chaturvedi, N, Soedamah-Muthu, S S, Durazzo, M & Gruden, G 2022, 'Association of serum MicroRNA-145-5p levels with microvascular complications of type 1 Diabetes : The EURODIAB prospective complications study', Diabetes Research and Clinical Practice, vol. 190, 109987. https://doi.org/10.1016/j.diabres.2022.109987
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info:eu-repo/semantics/openAccess