Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry
Verhaar,S. Vissers,P.A.J. Maas,H. van de Poll-Franse,L.V. van Erning,F.N. Mols,F.
Verhaar,S.
Vissers,P.A.J.
Maas,H.
van de Poll-Franse,L.V.
van Erning,F.N.
Mols,F.
Abstract
Background The goal of this study was to compare health related quality of life (HRQoL) and disease-specific symptoms between colon cancer patients treated with surgery only (SU) and surgery and adjuvant chemotherapy (SU + adjCT). Results were stratified for those aged <70 and ⩾70 years. HRQoL of patients was also compared with an age- and sex-matched normative population. Methods Patients diagnosed with colon cancer between January 2000 and June 2009, as registered within the population-based Eindhoven Cancer Registry, received a questionnaire on HRQoL (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire version 3.0 (QLQ-C30)) and disease-specific symptoms (EORTC QLQ-Colorectal 38 (EORTC QLQ-CR38)) in 2010. The first was also completed by the normative population (n = 685). Results 1606 (72%) colon cancer survivors responded to our questionnaire. 1542 colon cancer patients treated with SU (n = 1031) or SU + adjCT (n = 493) were included in this study. In colon cancer patients aged <70 years and aged ⩾70 no statistical significant differences on the subscales of the EORTC QLQ-C30 or the EORTC QLQ-CR38 were observed between patients treated with SU and SU + adjCT. Colon cancer patients aged <70 years either treated with SU or SU + adjCT reported significantly more insomnia, diarrhoea and financial problems compared with the normative population. No differences in HRQoL were found between colon cancer patients aged ⩾70 years either treated with SU or SU + adjCT and the normative population. Conclusion No differences in HRQoL and disease-specific symptoms were found between patients treated with SU versus SU + adjCT in both younger and elderly colon cancer patients. Withholding patients adjCT, based on concerns for long-term HRQoL or disease-specific symptoms does therefore not seem plausible.Keywords: Colon cancer, Quality of life, Elderly, Adjuvant chemotherapy
Description
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
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Journal Issue
Keywords
SDG 3 - Good Health and Well-being
Citation
Verhaar, S, Vissers, P A J, Maas, H, van de Poll-Franse, L V, van Erning, F N & Mols, F 2015, 'Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors : Results from the population-based PROFILES registry', European Journal of Cancer, vol. 51, no. 10, pp. 1263–1273. https://doi.org/10.1016/j.ejca.2015.04.004
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info:eu-repo/semantics/closedAccess