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The impact of prostate cancer diagnosis and treatment decision-making on health-related quality of life before treatment onset
Cuypers,M. Lamers,R. Cornel,E.B. van de Poll-Franse,L.V. de Vries,M. Kil,P.J.M.
Cuypers,M.
Lamers,R.
Cornel,E.B.
van de Poll-Franse,L.V.
de Vries,M.
Kil,P.J.M.
Abstract
Objective: The objective of this study is to test if patients' health-related quality of life (HRQoL) declines after prostate biopsy to detect Pca, and after subsequent treatment decision-making in case Pca is confirmed, and to test whether personality state and traits are associated with these potential changes in HRQoL. Methods: Patients who were scheduled for prostate biopsy to detect Pca (N = 377) filled out a baseline questionnaire about HRQoL (EORTC QLQ-C30 and PR25), "big five" personality traits (BFI-10), optimism (LOT-r), and self-efficacy (Decision Self-efficacy Scale) (t0). Patients with confirmed Pca (N = 126) filled out a follow-up questionnaire on HRQoL within 2 weeks after treatment was chosen but had not yet started (t1). Results: HRQoL declined between t0 and t1, reflected in impaired role and cognitive functioning, and elevated fatigue, constipation, and prostate-specific symptoms. Sexual activity and functioning improved. Baseline HRQoL scores were unrelated to the selection of a particular treatment, but for patients who chose a curative treatment, post-decision HRQoL showed a greater decline compared to patients who chose active surveillance. Optimism was associated with HRQoL at baseline; decisional self-efficacy was positively associated with HRQoL at follow-up. No associations between HRQoL and the "big five" personality traits were found. Conclusion: Patients who have undergone prostate biopsy and treatment decision-making for Pca experience a decline in HRQoL. Choosing treatment with a curative intent was associated with greater decline in HRQoL. Interventions aimed at optimism and decision self-efficacy could be helpful to reduce HRQoL impairment around the time of prostate biopsy and treatment decision-making
Description
Date
2018
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Volume Title
Publisher
Research Projects
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Keywords
ACTIVE SURVEILLANCE, Cancer, DISTRESS, Decision-making, Decisional self-efficacy, Diagnosis, HRQoL, MEN, OLDER AMERICANS, Oncology, Optimism, PERSONALITY, Prostate cancer, SURVIVORS, THREAT, URINARY, SDG 3 - Good Health and Well-being
Citation
Cuypers, M, Lamers, R, Cornel, E B, van de Poll-Franse, L V, de Vries, M & Kil, P J M 2018, 'The impact of prostate cancer diagnosis and treatment decision-making on health-related quality of life before treatment onset', Supportive Care in Cancer, vol. 26, no. 4, pp. 1297-1304. https://doi.org/10.1007/s00520-017-3953-8