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Longitudinal associations of adherence to the world cancer research fund/american institute for cancer research (wcrf/aicr) lifestyle recommendations with quality of life and symptoms in colorectal cancer survivors up to 24 Months post-treatment
Kenkhuis,M.F. Mols,F. van Roekel,E.H. Breedveld - Peters,J.J.L. Breukink,S.O. Janssen-Heijnen,M.L.G. Keulen,E.T.P. van Duijnhoven,F.J.B. Weijenberg,M.P. Bours,M.J.L.
Kenkhuis,M.F.
Mols,F.
van Roekel,E.H.
Breedveld - Peters,J.J.L.
Breukink,S.O.
Janssen-Heijnen,M.L.G.
Keulen,E.T.P.
van Duijnhoven,F.J.B.
Weijenberg,M.P.
Bours,M.J.L.
Abstract
Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (n = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study
Description
This study was funded by the Wereld Kanker Onderzoek Fonds (WKOF)/World Cancer Research Fund (WCRF: 2017/1619). M. Kenkhuis is supported by a grant from WKOF/WCRF 2017/1619. The EnCoRe study was also supported by Stichting Alpe d’Huzes within the research program “Leven met kanker” of the Dutch Cancer Society grants UM 2010-4867 and UM 2012-5653, by ERA-NET on Translational Cancer Research (TRANSCAN: Dutch Cancer Society (UM 2014-6877), and by Kankeronderzoekfonds Limburg as part of Health Foundation Limburg grant 00005739. E.H. van Roekel is funded by WKOF/WCRF 2016/1620.
Date
2022
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Research Projects
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Keywords
CHEMOTHERAPY, DIET, EORTC QLQ-C30, EUROPEAN-ORGANIZATION, FATIGUE, HEALTH, INDUCED PERIPHERAL NEUROPATHY, PHYSICAL-ACTIVITY, QUESTIONNAIRE, VALIDATION, chemotherapy-induced peripheral neuropathy, colorectal cancer survivorship, fatigue, health-related quality of life, lifestyle recommendations, SDG 3 - Good Health and Well-being
Citation
Kenkhuis, M F, Mols, F, van Roekel, E H, Breedveld - Peters, J J L, Breukink, S O, Janssen-Heijnen, M L G, Keulen, E T P, van Duijnhoven, F J B, Weijenberg, M P & Bours, M J L 2022, 'Longitudinal associations of adherence to the world cancer research fund/american institute for cancer research (wcrf/aicr) lifestyle recommendations with quality of life and symptoms in colorectal cancer survivors up to 24 Months post-treatment', Cancers, vol. 14, no. 2, 417. https://doi.org/10.3390/cancers14020417
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info:eu-repo/semantics/openAccess