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Sociodemographic, clinical, lifestyle, and psychological correlates of peripheral neuropathy among 2- to 12-year colorectal cancer survivors
Révész,D. Bonhof,C.S. Bours,M.J.L. Weijenberg,M.P. Vreugdenhil,G. van de Poll-Franse,L.V. Mols,F.
Révész,D.
Bonhof,C.S.
Bours,M.J.L.
Weijenberg,M.P.
Vreugdenhil,G.
van de Poll-Franse,L.V.
Mols,F.
Abstract
Background Peripheral neuropathy (PN) is a debilitating complication among colorectal cancer (CRC) survivors that can become chronic. No large-scale study has yet analyzed correlates in multivariable models. We did multivariable analyses to find correlates of PN. Methods In 1,516 all-stage Dutch CRC survivors, cross-sectional data were collected on sensory, motor, autonomic and total PN, sociodemographic (age, sex, education, employment, partner), clinical (time since diagnosis, tumor location, stage, chemotherapy, radiotherapy, co-morbidities), lifestyle (alcohol, smoking, physical activity, body mass index), psychological factors (anxiety, depression, personality) and health-related quality of life (HRQoL). After multiple imputation, correlates were analyzed with linear regressions and eliminated with backwards selection. Results CRC survivors (69 years; 42% female) were on average five years post-diagnosis, and 28-65% reported PN. PN was associated with older age, being male (sensory) or female (motor), shorter time since diagnosis, chemotherapy, co-morbidities, anxiety, depression, and worse scores on HRQoL domains, and pain, nausea, vomiting, insomnia, constipation and financial problems. Conclusions In multivariable analyses, PN is affected by receiving chemotherapy, aging, sex, co-morbidities, stress-related factors and HRQoL in CRC survivors. Future PN-related studies can include these factors, and they can be examined in longitudinal studies to gain more knowledge about chronicity and severity of PN.
Description
This work was supported by an NWO Aspasia Grant (NWO#015.012.023). Martijn J.L. Bours is supported by the Kankeronderzoekfonds Limburg as part of Health Foundation Limburg (grant No. 00005739).
Date
2022
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Research Projects
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Keywords
ANXIETY, ASSOCIATION, CHEMOTHERAPY, Cancer survivors, Colorectal cancer, EORTC QLQ-CIPN20, EUROPEAN-ORGANIZATION, PREVENTION, Peripheral neuropathy, Psychological stress, QUALITY-OF-LIFE, QUESTIONNAIRE, Quality of life, RELATIVE VALIDITY, REPRODUCIBILITY, SDG 3 - Good Health and Well-being, SDG 5 - Gender Equality
Citation
Révész, D, Bonhof, C S, Bours, M J L, Weijenberg, M P, Vreugdenhil, G, van de Poll-Franse, L V & Mols, F 2022, 'Sociodemographic, clinical, lifestyle, and psychological correlates of peripheral neuropathy among 2- to 12-year colorectal cancer survivors', Oncology Research and Treatment, vol. 45, no. 9, pp. 480-492. https://doi.org/10.1159/000524037