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rTMS for enhancing cognitive reserve: A case report
Fazio,Chiara Di Scaliti,Eugenio Stanziano,Mario Nigri,Anna Demichelis,Greta Tamietto,Marco Palermo,Sara
Fazio,Chiara Di
Scaliti,Eugenio
Stanziano,Mario
Nigri,Anna
Demichelis,Greta
Tamietto,Marco
Palermo,Sara
Abstract
Understanding the mechanisms underlying brain ageing and age-related pathologies is crucial for addressing cognitive decline. Non-invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation (rTMS) have gained prominence due to their ability to modulate neurophysiological, affective and cognitive brain functions. In this case study, we present a 61-year-old woman who suffered from mood disturbances, sleep disturbances, fatigue and cognitive decline. A comprehensive neuropsychological assessment was performed to evaluate mood, cognition and quality of life. The elderly woman underwent rTMS treatment targeting the left dorsolateral prefrontal cortex (DLPFC), a region critical for executive functions and mood regulation. Significant improvements were observed in attention, processing speed, and cognitive flexibility, as evidenced by reductions in completion times on the Trail Making Test (TMT). In addition to clinical and cognitive outcomes, cortical excitability was assessed through motor-evoked potentials (MEPs) before and after the intervention. Modulation of MEPs amplitude was observed post-treatment, suggesting neurophysiological changes potentially linked to the normalization of cortical activity. Our findings suggest that rTMS may be a well-tolerated and potentially effective intervention for improving cognitive function and stabilizing mood in older adults experiencing age-related cognitive decline and mood disorders.
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2025-06-01
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Keywords
brain ageing, brain plasticity, repetitive transcranial magnetic stimulation (rTMS), high-frequency repetitive TMS, frailty, cognition, quality of life, dorsolateral prefrontal cortex (DLPFC)
Citation
Fazio, C D, Scaliti, E, Stanziano, M, Nigri, A, Demichelis, G, Tamietto, M & Palermo, S 2025, 'rTMS for enhancing cognitive reserve : A case report', Brain Disorders, vol. 18, 100221. https://doi.org/10.1016/j.dscb.2025.100221
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info:eu-repo/semantics/openAccess