External validation of a prediction model for timely implementation of innovations in radiotherapy
Swart,Rachelle R. Fijten,Rianne Boersma,Liesbeth J. Kalendralis,Petros Behrendt,Myra D. Ketelaars,Martijn Roumen,Cheryl Jacobs,Maria J.G.
Swart,Rachelle R.
Fijten,Rianne
Boersma,Liesbeth J.
Kalendralis,Petros
Behrendt,Myra D.
Ketelaars,Martijn
Roumen,Cheryl
Jacobs,Maria J.G.
Abstract
Background and purpose: The aim of this study was to externally validate a model that predicts timely innovation implementation, which can support radiotherapy professionals to be more successful in innovation implementation. Materials and methods: A multivariate prediction model was built based on the TRIPOD (Transparent Reporting of a multivariate prediction model for Individual Prognosis Or Diagnosis) criteria for a type 4 study (1). The previously built internally validated model had an AUC of 0.82, and was now validated using a completely new multicentre dataset. Innovation projects that took place between 2017–2019 were included in this study. Semi-structured interviews were performed to retrieve the prognostic variables of the previously built model. Projects were categorized according to the size of the project; the success of the project and the presence of pre-defined success factors were analysed. Results: Of the 80 included innovation projects (32.5% technological, 35% organisational and 32.5% treatment innovations), 55% were successfully implemented within the planned timeframe. Comparing the outcome predictions with the observed outcomes of all innovations resulted in an AUC of the external validation of the prediction model of 0.72 (0.60–0.84, 95% CI). Factors related to successful implementation included in the model are sufficient and competent employees, desirability and feasibility, clear goals and processes and the complexity of a project. Conclusion: For the first time, a prediction model focusing on the timely implementation of innovations has been successfully built and externally validated. This model can now be widely used to enable more successful innovation in radiotherapy.
Description
Funding Information: We thank Southwest Radiotherapy Institute (ZRTI) and Leiden University Medical Center Department of Radiation Oncology for participating in this study, providing us with projects implemented in their centre. We also thank all interviewees for taking the time to provide us with insides into the projects. Publisher Copyright: © 2023 The Author(s)
Date
2023-02
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Research Projects
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Keywords
External validation, Innovation implementation, Radiotherapy, TRIPOD type 4
Citation
Swart, R R, Fijten, R, Boersma, L J, Kalendralis, P, Behrendt, M D, Ketelaars, M, Roumen, C & Jacobs, M J G 2023, 'External validation of a prediction model for timely implementation of innovations in radiotherapy', Radiotherapy and Oncology, vol. 179, 109459. https://doi.org/10.1016/j.radonc.2022.109459
License
info:eu-repo/semantics/openAccess