Loading...
Risk factors for atopic diseases and recurrent respiratory tract infections in children
Kansen,H. M. Lebbink,M. A. de Mul,J. van Erp,F. C. van Engelen,M. de Vries,E. Prevaes,S. M. P. J. Le ,T. M. van der Ent,C. K. Verhagen,L. M.
Kansen,H. M.
Lebbink,M. A.
de Mul,J.
van Erp,F. C.
van Engelen,M.
de Vries,E.
Prevaes,S. M. P. J.
Le ,T. M.
van der Ent,C. K.
Verhagen,L. M.
Abstract
Introduction: The simultaneously increased prevalence of atopic diseases and decreased prevalence of infectious diseases might point to a link between the two entities. Past work mainly focused on either atopic diseases or recurrent infections. We aim to investigate whether risk factors for atopic diseases (ie, asthma, allergic rhinitis, atopic dermatitis, and/or food allergy) differ from risk factors for recurrent respiratory tract infections (RRTIs) in children. Methods: Cross-sectional data were used from 5517 children aged 1 to 18 years who participated in an Electronic Portal for children between 2011 and 2019. Univariable/multivariable logistic regression analyses were performed to determine risk factors for any atopic disease and RRTIs. Results: Children aged ≥5 years were more likely to have any atopic disease (adjusted odds ratio [OR]: 1.50-2.77) and less likely to have RRTIs (OR: 0.68-0.84) compared to children aged less than 5 years. Female sex (OR: 0.72; 95% confidence interval [CI]: 0.63-0.81), low birth weight (OR: 0.74; 95% CI: 0.57-0.97) and dog ownership (OR: 0.79; 95% CI: 0.66-0.95) reduced the odds of any atopic disease, but not of RRTIs. Daycare attendance (OR: 1.22; 95% CI: 1.02-1.47) was associated with RRTIs, but not with atopic diseases. A family history of asthma, allergic rhinitis, atopic dermatitis, and RRTIs was significantly associated with the same entity in children, with OR varying from 1.58 (95% CI: 1.35-1.85) in allergic rhinitis to 2.20 (95% CI: 1.85-2.61) in asthma. Conclusion: Risk factors for atopic diseases are distinct from risk factors for RRTIs, suggesting that the changing prevalence of both entities is not related to shared risk factors.
Description
Funding Information: The study was partly supported by a grant from the WKZ Utrecht (Wilhelmina Children's Hospital) Research Fund (contact name Dr Lilly M. Verhagen). Dr Lilly M. Verhagen also received a Fellowship clinical research talent UMC Utrecht. The Electronic Portal was supported by an unrestricted grant of GlaxoSmithKline (contact name Prof Dr Cornelis K. van der Ent).
Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue
Keywords
ALLERGY, ASTHMA, CHILDHOOD, COHORT, IMMUNOLOGY, RATIONALE, atopic disease, atopy, children, recurrent infection, respiratory tract infections, risk factors, SDG 3 - Good Health and Well-being
Citation
Kansen, H M, Lebbink, M A, de Mul, J, van Erp, F C, van Engelen, M, de Vries, E, Prevaes, S M P J, Le , T M, van der Ent, C K & Verhagen, L M 2020, 'Risk factors for atopic diseases and recurrent respiratory tract infections in children', Pediatric Pulmonology, vol. 55, no. 11, pp. 3168-3179. https://doi.org/10.1002/ppul.25042
License
info:eu-repo/semantics/openAccess