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Executive functional deficits during electrical stimulation of the right frontal aslant tract
Rutten,Geert-Jan Landers,Maud De Baene,Wouter Meijerink,Tessa van der Hek,Stephanie Verheul,Jeroen H.B.
Rutten,Geert-Jan
Landers,Maud
De Baene,Wouter
Meijerink,Tessa
van der Hek,Stephanie
Verheul,Jeroen H.B.
Abstract
Direct electrical stimulation mapping was used to map executive functions during awake surgery of a patient with a right frontal low-grade glioma. We specifically targeted the frontal aslant tract, as this pathway had been infiltrated by the tumor. The right frontal aslant tract has been implicated in executive functions in the neuroscientific literature, but is yet of unknown relevance for clinical practice. Guided by tractography, electrical stimulation of the frontal aslant tract disrupted working memory and inhibitory functions. In this report we illustrate the dilemmas that neurosurgeons face when balancing maximal tumor resection against optimal cognitive performance. In particular, we emphasize that intraoperative tasks that target cognitive functions should be carefully introduced in clinical practice to prevent clinically irrelevant responses and too early termination of the resection.
Description
Ethics approval This study was approved by the local ethics committee (METC Brabant, The Netherlands).
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
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Journal Issue
Keywords
Brain Mapping, Brain Neoplasms/diagnostic imaging, Electric Stimulation, Frontal Lobe/diagnostic imaging, Humans, Magnetic Resonance Imaging, Wakefulness
Citation
Rutten, G-J, Landers, M, De Baene, W, Meijerink, T, van der Hek, S & Verheul, J H B 2021, 'Executive functional deficits during electrical stimulation of the right frontal aslant tract', Brain Imaging and Behavior, vol. 15, no. 5, pp. 2731-2735. https://doi.org/10.1007/s11682-020-00439-8
License
info:eu-repo/semantics/openAccess