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Longitudinal associations of sociodemographic, lifestyle, and clinical factors with alcohol consumption in colorectal cancer survivors up to 2 years post-diagnosis
Révész,D. Bours,M.J. Wegdam,J.A. Keulen,E.T.P. Breukink,S.O. Slooter,G.D. Vogelaar,F.J. Weijenberg,M.P. Mols,F.
Révész,D.
Bours,M.J.
Wegdam,J.A.
Keulen,E.T.P.
Breukink,S.O.
Slooter,G.D.
Vogelaar,F.J.
Weijenberg,M.P.
Mols,F.
Abstract
Purpose Alcohol consumption can lead to worse prognosis and mortality among colorectal cancer (CRC) patients. We investigated alcohol consumption of CRC survivors up to 2 years post-diagnosis, and how sociodemographic, lifestyle, and clinical factors were associated longitudinally with these habits. Methods We pooled longitudinal data of 910 CRC survivors from the ongoing PROCORE and EnCoRe studies with data collected at diagnosis (baseline) and 3, 6, 12, and 24 months post-diagnosis. Both studies assessed alcohol consumption, including beer, wine, and liquor. Generalized estimated equation models were used to examine changes over time in alcohol consumption and multivariable longitudinal associations of sociodemographic, lifestyle, and clinical factors with alcohol consumption. Results At baseline, participants were on average 67 years old, 332 (37%) were female, and alcohol was consumed by 79%. Most survivors (68-71%) drank less at all follow-ups. Beer, wine, and liquor were consumed by 51%, 58%, and 25% at baseline, respectively, and these declined over time. Males consumed more alcohol, and higher education, more physical activity, and not having a (permanent) stoma were associated with consuming more alcohol. Conclusion CRC survivors decreased their alcohol consumption in the 2 years post-diagnosis. Future studies should take the significant factors that were associated with alcohol post-diagnosis consumption into account, when they investigate CRC health outcomes or for identifying subgroups for interventions. Males with higher education, more physical activity, and no stoma should be reminded after diagnosis for reducing their alcohol consumption.
Description
Funding The current study was supported by ERAB: The European Foundation for Alcohol Research (number EA 18 20). The EnCoRe study was supported by grants from the Stichting Alpe d’HuZes within the research program “Leven met kanker” of the Dutch Cancer Society (Grant Nos. UM2010-4867 and UM-2012-5653), grants from Kankeronderzoekfonds Limburg as part of Health Foundation Limburg (Grant No. 00005739), Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (grant number 2016/1620), and ERA-NET on Translational Cancer Research (TRANSCAN/Dutch Cancer Society, the Netherlands, project no. UM 2014-6877).
Date
2021
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Research Projects
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Keywords
Alcohol drinking, Cancer survivors, Colorectal cancer, Longitudinal studies, SDG 3 - Good Health and Well-being
Citation
Révész, D, Bours, M J, Wegdam, J A, Keulen, E T P, Breukink, S O, Slooter, G D, Vogelaar, F J, Weijenberg, M P & Mols, F 2021, 'Longitudinal associations of sociodemographic, lifestyle, and clinical factors with alcohol consumption in colorectal cancer survivors up to 2 years post-diagnosis', Supportive Care in Cancer, vol. 29, no. 10, pp. 5935-5943. https://doi.org/10.1007/s00520-021-06104-0