Does extended surgery influence health-related quality of life in patients with rectal cancer?
Orsini,R. Vermeer,T.A. Traa,M.J. Nieuwenhuijzen,G.A.P. de Hingh,I.H.J.T. Rutten,H.J.
Orsini,R.
Vermeer,T.A.
Traa,M.J.
Nieuwenhuijzen,G.A.P.
de Hingh,I.H.J.T.
Rutten,H.J.
Abstract
Background: In locally advanced rectal cancer, an extended resection peripheral to the mesorectal fascia is needed to achieve a radical resection. The influence of extended resections on health-related quality of life is unclear. Objective: Differences in health-related quality of life and sexuality between patients receiving standard surgery and patients receiving extended surgery were examined, with a focus on age. Design: Patients operated on for rectal cancer between 2000 and 2010 were selected from a database and invited to complete the European Organization for Research and Treatment of Cancer quality-of-life questionnaires (C30 and ColoRectal 38). Settings: All patients were treated at the Catharina Hospital, Eindhoven, the Netherlands. Patients: All patients received total mesorectal excision surgery or extended surgery for rectal cancer. Main outcome measures: Health-related quality of life and sexual activity was compared between patients treated with total mesorectal excision surgery and extended surgery and further stratified by age at the time of surgery (<70 and ≥70).RESULTS: Two hundred twenty-nine (64.1%) patients with standard surgery and 128 (35.9%) patients treated with extended resections responded. Extended surgery in patients <70 years resulted in lower body image compared with patients <70 years receiving standard surgery. Patients ≥70 years had lower sexual function and more male sexual dysfunction than patients <70 years undergoing standard surgery. In all groups, sexual activity dropped significantly after treatment.LIMITATIONS: No information was available of the patients' health-related quality of life before treatment except for the retrospective question about sexual activity. Conclusions: This study showed no major differences between patients undergoing total mesorectal excision surgery and those receiving extended surgery, with the exception of body image, which was significantly lower in patients <70 years undergoing extended surgery. In all patient groups, treatment for rectal cancer influenced sexual activity dramatically. Awareness of the impact of surgery on health-related quality of life and sexuality is needed.
Description
Date
2015
Journal Title
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Volume Title
Publisher
Research Projects
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Keywords
SDG 3 - Good Health and Well-being
Citation
Orsini, R, Vermeer, T A, Traa, M J, Nieuwenhuijzen, G A P, de Hingh, I H J T & Rutten, H J 2015, 'Does extended surgery influence health-related quality of life in patients with rectal cancer?', Diseases of the Colon & Rectum, vol. 58, no. 2, pp. 179-185. https://doi.org/10.1097/DCR.0000000000000292