Comparison of two automated oxygen controllers in oxygen targeting in preterm infants during admission:: an observational study
Salverda,Hylke H. Dekker,Janneke Lopriore,Enrico Dargaville,Peter A. Pauws,Steffen C. te Pas,Arjan B.
Salverda,Hylke H.
Dekker,Janneke
Lopriore,Enrico
Dargaville,Peter A.
Pauws,Steffen C.
te Pas,Arjan B.
Abstract
Objective To compare the effect of two different automated oxygen control devices on time preterm infants spent in different oxygen saturation (SpO 2) ranges during their entire stay in the neonatal intensive care unit (NICU). Design Retrospective cohort study of prospectively collected data. Setting Tertiary level neonatal unit in the Netherlands. Patients Preterm infants (OxyGenie 75 infants, CLiO 2 111 infants) born at 24-29 weeks' gestation receiving at least 72 hours of respiratory support between October 2015 and November 2020. Interventions Inspired oxygen concentration was titrated by the OxyGenie controller (SLE6000 ventilator) between February 2019 and November 2020 and the CLiO 2 controller (AVEA ventilator) between October 2015 and December 2018 as standard of care. Main outcome measures Time spent within SpO 2 target range (TR, 91-95% for either epoch) and other SpO 2 ranges. Results Time spent within the SpO 2 TR when receiving supplemental oxygen was higher during OxyGenie control (median 71.5 [IQR 64.6-77.0]% vs 51.3 [47.3-58.5]%, p<0.001). Infants under OxyGenie control spent less time in hypoxic and hyperoxic ranges (SpO 2 <80%: 0.7 [0.4-1.4]% vs 1.2 [0.7-2.3]%, p<0.001; SpO2>98%: 1.0 [0.5-2.4]% vs 4.0 [2.0-7.9]%, p<0.001). Both groups received a similar FiO 2 (29.5 [28.0-33.2]% vs 29.6 [27.7-32.1]%, p=not significant). Conclusions Oxygen saturation targeting was significantly different in the OxyGenie epoch in preterm infants, with less time in hypoxic and hyperoxic SpO 2 ranges during their stay in the NICU.
Description
Publisher Copyright: © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
Date
2023-07-01
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue
Keywords
Neonatology, Respiratory Medicine, Inspired Oxygen, Saturation, Episodes
Citation
Salverda, H H, Dekker, J, Lopriore, E, Dargaville, P A, Pauws, S C & te Pas, A B 2023, 'Comparison of two automated oxygen controllers in oxygen targeting in preterm infants during admission: an observational study', Archives of Disease in Childhood. Fetal and Neonatal Edition, vol. 108, no. 4, pp. 394-399. https://doi.org/10.1136/archdischild-2022-324819