Longitudinal associations of chemotherapy-induced peripheral neuropathy with psychological distress and health-related quality of life in colorectal cancer survivors: A prospective cohort study
Boekhoudt,N.D. Mols,F. Simons,C. Querido,N.R. Breukink,S.O. Valkenburg van Iersel,L. Janssen-Heijnen,M.L.G. Keulen,E.T.P. Weijenberg,M.P. Bours,M.J.L.
Boekhoudt,N.D.
Mols,F.
Simons,C.
Querido,N.R.
Breukink,S.O.
Valkenburg van Iersel,L.
Janssen-Heijnen,M.L.G.
Keulen,E.T.P.
Weijenberg,M.P.
Bours,M.J.L.
Abstract
Purpose Colorectal cancer (CRC) survivors receiving oxaliplatin-based chemotherapy frequently develop chemotherapy-induced peripheral neuropathy (CIPN). This study investigated the impact of CIPN symptoms on psychological distress and health-related quality of life (HRQoL) among oxaliplatin-treated CRC survivors up to 5 years post-treatment. Methods 124 CRC patients treated with oxaliplatin-based chemotherapy participating in a prospective cohort study were included in the longitudinal analyses. CIPN symptoms were measured at diagnosis (pre-treatment) and at 6 weeks and 6, 12, 24, and 60 months post-treatment using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-CIPN20 (EORTC QLQ-CIPN20). Psychological distress, including anxiety and depressive symptoms, and HRQoL were measured at all post-treatment time points using the Hospital Anxiety and Depression Scale (HADS) and the EORTC QLQ-Core 30 (EORTC QLQ-C30), respectively. Confounder-adjusted longitudinal associations of CIPN symptoms with psychological distress and HRQoL were analysed with linear mixed regression models. Results CIPN symptoms in oxaliplatin-treated CRC patients were highest at 6 weeks post-treatment, thereafter gradually decreasing over time. More severe CIPN symptoms were longitudinally associated with more psychological distress (HADS), including both higher anxiety and depressive symptoms, and with worse global health/QoL and physical and social functioning and more fatigue (EORTC QLQ-C30). Conclusion CIPN symptoms, persisting over time among oxaliplatin-treated CRC survivors, were longitudinally associated with more psychological distress and lower HRQoL up to 5 years after chemotherapy treatment.
Description
Date
2025-11
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue
Keywords
Colorectal cancer, Cancer survivors, Chemotherapy-induced peripheral neuropathy, Psychological distress, Health-related quality of life, SDG 3 - Good Health and Well-being
Citation
Boekhoudt, N D, Mols, F, Simons, C, Querido, N R, Breukink, S O, Valkenburg van Iersel, L, Janssen-Heijnen, M L G, Keulen, E T P, Weijenberg, M P & Bours, M J L 2025, 'Longitudinal associations of chemotherapy-induced peripheral neuropathy with psychological distress and health-related quality of life in colorectal cancer survivors : A prospective cohort study', Journal of Cancer Survivorship. https://doi.org/10.1007/s11764-025-01906-1
License
info:eu-repo/semantics/openAccess