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Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe
Boccardi,Marina Monsch,Andreas U Ferrari,Clarissa Altomare,Daniele Berres,Manfred Bos,Isabelle Buchmann,Andreas Cerami,Chiara Didic,Mira Festari,Cristina
Boccardi,Marina
Monsch,Andreas U
Ferrari,Clarissa
Altomare,Daniele
Berres,Manfred
Bos,Isabelle
Buchmann,Andreas
Cerami,Chiara
Didic,Mira
Festari,Cristina
Abstract
Introduction: Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts. Methods: To harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeholders, methodologists, academic, and non-academic clinicians and experts from European, US, and Australian harmonization initiatives. Results: With formal presentations and thematic working-groups we defined a standard battery consistent with the U.S. Uniform DataSet, version 3, and homogeneous methodology to obtain consistent normative data across tests and languages. Adaptations consist of including two tests specific to typical Alzheimer's disease and behavioral variant frontotemporal dementia. The methodology for harmonized normative data includes consensus definition of cognitively normal controls, classification of confounding factors (age, sex, and education), and calculation of minimum sample sizes. Discussion: This expert consensus allows harmonizing the diagnosis of neurocognitive disorders across European countries and possibly beyond.
Description
Funding information: The Geneva Workshop was funded by the Swiss National Science Foundation (grant number ISZEZO_180198), Alzheimer Forum Switzerland and MindMaze. M. Boccardi was supported in part by the EU-EFPIA Innovative Medicines Initiatives 2 Joint Undertaking (grant no. 115952; recipient: Giovanni Frisoni, AMYPAD project). I. Bos and P.J. Visser were supported by the Innovative Medicine Initiative Joint Undertaking. P.J.V. participation was also supported by ZONmW. The participation of W. Kukull was supported by NIH (U01 AG016976); participation of P. Sachdev was supported by NHMRC Australia. C. Ferrari was supported by the Italian Ministry of Health (Ricerca Corrente).
Date
2022
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Research Projects
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Keywords
ALZHEIMERS-DISEASE, AMNESTIC SYNDROME, Alzheimer&apos, BEHAVIORAL VARIANT, COGNITIVE IMPAIRMENT, CONSENSUS STATEMENT, DATA SET UDS, DIFFERENTIAL-DIAGNOSIS, MONTE-CARLO, SAMPLE-SIZE, SELECTIVE REMINDING TEST, cognitive assessment, diagnosis, mild cognitive impairment, mild neurocognitive disorders, s disease, standard neuropsychological assessment
Citation
Boccardi, M, Monsch, A U, Ferrari, C, Altomare, D, Berres, M, Bos, I, Buchmann, A, Cerami, C, Didic, M, Festari, C, Nicolosi, V, Sacco, L, Aerts, L, Albanese, E, Annoni, J-M, Ballhausen, N, Chicherio, C, Démonet, J-F, Descloux, V, Diener, S, Ferreira, D, Georges, J, Gietl, A, Girtler, N, Kilimann, I, Klöppel, S, Kustyniuk, N, Mecocci, P, Mella, N, Pigliautile, M, Seeher, K, Shirk, S D, Toraldo, A, Brioschi-Guevara, A, Chan, K C G, Crane, P K, Dodich, A, Grazia, A, Kochan, N A, de Oliveira, F F, Nobili, F, Kukull, W, Peters, O, Ramakers, I, Sachdev, P S, Teipel, S, Visser, P J, Wagner, M, Weintraub, S, Westman, E & Consortium for the Harmonization of Neuropsychological Assessment for Neurocognitive Disorders (https://nextcloud.dzne.de/index.php/s/EwXjLab9caQTbQe) 2022, 'Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe', Alzheimers & Dementia, vol. 18, no. 1, pp. 29-42. https://doi.org/10.1002/alz.12365