Inducing a mental context for associative memory formation with real-time fMRI neurofeedback
Collin,Silvy H P van den Broek,Philip van Mourik,tim Desain,Peter Doeller,Christian F
Collin,Silvy H P
van den Broek,Philip
van Mourik,tim
Desain,Peter
Doeller,Christian F
Abstract
Memory, one of the hallmarks of human cognition, can be modified when humans voluntarily modulate neural population activity using neurofeedback. However, it is currently unknown whether neurofeedback can influence the integration of memories, and whether memory is facilitated or impaired after such neural perturbation. In this study, participants memorized objects while we provided them with abstract neurofeedback based on their brain activity patterns in the ventral visual stream. This neurofeedback created an implicit face or house context in the brain while memorizing the objects. The results revealed that participants created associations between each memorized object and its implicit context solely due to the neurofeedback manipulation. Our findings shed light onto how memory formation can be influenced by synthetic memory tags with neurofeedback and advance our understanding of mnemonic processing.
Description
Funding Information: CFD’s research is funded by the Kavli Foundation, the Centre of Excellence scheme of the Research Council of Norway—Centre for Biology of Memory and Centre for Neural Computation, The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, the National Infrastructure scheme of the Research Council of Norway—NORBRAIN, the Netherlands Organisation for Scientific Research (NWO-Vidi 452-12-009; NWO-Gravitation 024-001-006; NWO-MaGW 406-14-114; NWO-MaGW 406-15-291) and the European Research Council (ERC-StG RECONTEXT 261177; ERC-CoG GEOCOG 724836). SHPC is supported by the Netherlands Organisation for Scientific Research (NWO-Rubicon Grant 446-17-009). The authors would like to thank Alejandro Vicente-Grabovetsky and Sander Bosch for technical support. Correspondence should be addressed to SHPC (S.H.P.Collin@tilburguniversity.edu) or CFD (doeller@cbs.mpg.de). Publisher Copyright: © 2022, The Author(s).
Date
2022-12
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Keywords
Humans, Magnetic Resonance Imaging, Memory, Brain Function
Citation
Collin, S H P, van den Broek, P, van Mourik, T, Desain, P & Doeller, C F 2022, 'Inducing a mental context for associative memory formation with real-time fMRI neurofeedback', Scientific Reports, vol. 12, no. 1, 21226, pp. 1-10. https://doi.org/10.1038/s41598-022-25799-7
License
info:eu-repo/semantics/openAccess