Alzheimer's disease heterogeneity revealed by neuroanatomical normative modeling
Loreto,Flavia Verdi,Serena Kia,Seyed Mostafa Duvnjak,Aleksandar Hakeem,Haneen Fitzgerald,Anna Patel,Neva Lilja,Johan Win,Zarni Perry,Richard
Loreto,Flavia
Verdi,Serena
Kia,Seyed Mostafa
Duvnjak,Aleksandar
Hakeem,Haneen
Fitzgerald,Anna
Patel,Neva
Lilja,Johan
Win,Zarni
Perry,Richard
Abstract
INTRODUCTION: Overlooking the heterogeneity in Alzheimer's disease (AD) may lead to diagnostic delays and failures. Neuroanatomical normative modeling captures individual brain variation and may inform our understanding of individual differences in AD-related atrophy. METHODS: We applied neuroanatomical normative modeling to magnetic resonance imaging from a real-world clinical cohort with confirmed AD ( n = 86). Regional cortical thickness was compared to a healthy reference cohort ( n = 33,072) and the number of outlying regions was summed (total outlier count) and mapped at individual- and group-levels. RESULTS: The superior temporal sulcus contained the highest proportion of outliers (60%). Elsewhere, overlap between patient atrophy patterns was low. Mean total outlier count was higher in patients who were non-amnestic, at more advanced disease stages, and without depressive symptoms. Amyloid burden was negatively associated with outlier count. DISCUSSION: Brain atrophy in AD is highly heterogeneous and neuroanatomical normative modeling can be used to explore anatomo-clinical correlations in individual patients.
Description
© 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Date
2024-01-01
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Research Projects
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Keywords
Alzheimer's disease, MRI, amyloid PET, heterogeneity, neuroanatomical normative modeling, neurodegeneration
Citation
Loreto, F, Verdi, S, Kia, S M, Duvnjak, A, Hakeem, H, Fitzgerald, A, Patel, N, Lilja, J, Win, Z, Perry, R, Marquand, A F, Cole, J H & Malhotra, P 2024, 'Alzheimer's disease heterogeneity revealed by neuroanatomical normative modeling', Alzheimer's & dementia (Amsterdam, Netherlands), vol. 16, no. 1, e12559, pp. e12559. https://doi.org/10.1002/dad2.12559
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info:eu-repo/semantics/openAccess