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Higher dietary magnesium intake and higher magnesium status are associated with lower prevalence of coronary heart disease in patients with type 2 diabetes
Gant,C.M. Soedamah-Muthu,S.S. Binnenmars,S.H. Bakker,S.J.L. Navis,G. Laverman,G.D.
Gant,C.M.
Soedamah-Muthu,S.S.
Binnenmars,S.H.
Bakker,S.J.L.
Navis,G.
Laverman,G.D.
Abstract
In type 2 diabetes mellitus (T2D), the handling of magnesium is disturbed. Magnesium deficiency may be associated with a higher risk of coronary heart disease (CHD). We investigated the associations between (1) dietary magnesium intake; (2) 24 h urinary magnesium excretion; and (3) plasma magnesium concentration with prevalent CHD in T2D patients. This cross-sectional analysis was performed on baseline data from the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1, n = 450, age 63 ± 9 years, 57% men, and diabetes duration of 11 (7-18) years). Prevalence ratios (95% CI) of CHD by sex-specific quartiles of magnesium indicators, as well as by magnesium intake per dietary source, were determined using multivariable Cox proportional hazard models. CHD was present in 100 (22%) subjects. Adjusted CHD prevalence ratios for the highest compared to the lowest quartiles were 0.40 (0.20, 0.79) for magnesium intake, 0.63 (0.32, 1.26) for 24 h urinary magnesium excretion, and 0.62 (0.32, 1.20) for plasma magnesium concentration. For every 10 mg increase of magnesium intake from vegetables, the prevalence of CHD was, statistically non-significantly, lower (0.75 (0.52, 1.08)). In this T2D cohort, higher magnesium intake, higher 24 h urinary magnesium excretion, and higher plasma magnesium concentration are associated with a lower prevalence of CHD.
Description
Date
2018
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Research Projects
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Keywords
Aged, Biomarkers/blood, Coronary Disease/diagnosis, Cross-Sectional Studies, Diabetes Mellitus, Type 2/diagnosis, Diet, Female, Humans, Magnesium Deficiency/diagnosis, Magnesium/administration & dosage, Male, Middle Aged, Netherlands/epidemiology, Nutritional Status, Prevalence, Protective Factors, Recommended Dietary Allowances, Risk Factors, SDG 3 - Good Health and Well-being
Citation
Gant, C M, Soedamah-Muthu, S S, Binnenmars, S H, Bakker, S J L, Navis, G & Laverman, G D 2018, 'Higher dietary magnesium intake and higher magnesium status are associated with lower prevalence of coronary heart disease in patients with type 2 diabetes', Nutrients, vol. 10, no. 3, 307. https://doi.org/10.3390/nu10030307
License
info:eu-repo/semantics/openAccess