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Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: Results from the population-based PROFILES registry
Bonhof,C.S. Trompetter,H.R. Vreugdenhil,G. van de Poll-Franse,L.V. Mols,F.
Bonhof,C.S.
Trompetter,H.R.
Vreugdenhil,G.
van de Poll-Franse,L.V.
Mols,F.
Abstract
Purpose This study aims to (1) examine the prevalence of painful versus non-painful chemotherapy-induced peripheral neuropathy (CIPN) among long-term colorectal cancer (CRC) survivors, (2) identify sociodemographic, clinical, and psychological factors associated with painful and non-painful CIPN, and (3) examine the associations of painful CIPN with health-related quality of life (HRQoL) in comparison with non-painful CIPN, i.e., numbness/tingling. Methods All CRC survivors diagnosed between 2000 and 2009 as registered by the population-based Netherlands Cancer Registry (Eindhoven region) were eligible for participation. Chemotherapy-treated survivors (n = 477) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30). Results Painful CIPN was reported by 9% (n = 45) of survivors and non-painful CIPN was reported by 22% (n = 103). Time since diagnosis was related to painful CIPN, and time since diagnosis, a higher disease stage, osteoarthritis, and more anxiety symptoms were related to non-painful CIPN. Finally, survivors with painful CIPN reported a worse global quality of life and worse physical, role, cognitive, and social functioning compared to survivors with non-painful CIPN and those without any sensory CIPN. No differences were found between survivors with non-painful CIPN and those without sensory CIPN. Conclusions It seems that painful CIPN must be distinguished from non-painful CIPN, as only painful CIPN was related to a worse HRQoL. Future research is needed to examine whether painful CIPN must be distinguished from non-painful CIPN regarding predictors, mechanisms, and treatment.
Description
Ethical approval This study was approved by a certified medical ethics committee.
Date
2020
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Publisher
Research Projects
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Keywords
ANXIETY, BREAST, Chemotherapy-induced peripheral neuropathy, Colorectal cancer, EUROPEAN-ORGANIZATION, Health-related quality of life, INSTRUMENT, Numbness, OXALIPLATIN, PREVALENCE, Pain, QUESTIONNAIRE, Tingling, SDG 3 - Good Health and Well-being
Citation
Bonhof, C S, Trompetter, H R, Vreugdenhil, G, van de Poll-Franse, L V & Mols, F 2020, 'Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors : Results from the population-based PROFILES registry', Supportive Care in Cancer, vol. 28, no. 12, pp. 5933-5941. https://doi.org/10.1007/s00520-020-05438-5