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Association between energy balance-related factors and clinical outcomes in patients with ovarian cancers: A systematic review and meta analysis
Stelten,S. Schofield,C. Hartman,Y.A.W. Lopez,P. Kenter,G.G. Newton,R.U. Galvao,D.A. Hoedjes,M. Taaffe,D.R. van Lonkhuijzen,L.R.C.W.
Stelten,S.
Schofield,C.
Hartman,Y.A.W.
Lopez,P.
Kenter,G.G.
Newton,R.U.
Galvao,D.A.
Hoedjes,M.
Taaffe,D.R.
van Lonkhuijzen,L.R.C.W.
Abstract
Background This systematic review and meta-analysis synthesized evidence in patients with ovarian cancer at diagnosis and/or during first-line treatment on; (i) the association of body weight, body composition, diet, exercise, sedentary behavior, or physical fitness with clinical outcomes; and (ii) the effect of exercise and/or dietary interventions. Methods Risk of bias assessments and best-evidence syntheses were completed. Meta-analyses were performed when ≥3 papers presented point estimates and variability measures of associations or effects. Results Body mass index (BMI) at diagnosis was not significantly associated with survival. Although the following trends were not supported by the best-evidence syntheses, the meta-analyses revealed that a higher BMI was associated with a higher risk of post-surgical complications (n = 5, HR: 1.63, 95% CI: 1.06–2.51, p = 0.030), a higher muscle mass was associated with a better progression-free survival (n = 3, HR: 1.41, 95% CI: 1.04–1.91, p = 0.030) and a higher muscle density was associated with a better overall survival (n = 3, HR: 2.12, 95% CI: 1.62–2.79, p < 0.001). Muscle measures were not significantly associated with surgical or chemotherapy-related outcomes. Conclusions The prognostic value of baseline BMI for clinical outcomes is limited, but muscle mass and density may have more prognostic potential. High-quality studies with comprehensive reporting of results are required to improve our understanding of the prognostic value of body composition measures for clinical outcomes. Systematic review registration number: PROSPERO identifier CRD42020163058.
Description
This research received no external funding.
Date
2022
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Publisher
Research Projects
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Keywords
BODY-MASS INDEX, CT-SCAN, DEBULKING SURGERY, FALLOPIAN-TUBE, NEOADJUVANT CHEMOTHERAPY, PHYSICAL-ACTIVITY, POOR-PROGNOSIS, PROGNOSTIC-FACTOR, PROGRESSION-FREE, SKELETAL-MUSCLE, body composition, diet, exercise, meta-analysis, ovarian cancer, SDG 3 - Good Health and Well-being
Citation
Stelten, S, Schofield, C, Hartman, Y A W, Lopez, P, Kenter, G G, Newton, R U, Galvao, D A, Hoedjes, M, Taaffe, D R, van Lonkhuijzen, L R C W, McIntyre, C & Buffart, L M 2022, 'Association between energy balance-related factors and clinical outcomes in patients with ovarian cancers : A systematic review and meta analysis', Cancers, vol. 14, no. 19, 4567. https://doi.org/10.3390/cancers14194567