Loading...
Hippocampal volume modulates salivary oxytocin level increases after intranasal oxytocin administration
Riem,M.M.E. Van Ijzendoorn,Marinus H. Bakermans-Kranenburg,Marian J.
Riem,M.M.E.
Van Ijzendoorn,Marinus H.
Bakermans-Kranenburg,Marian J.
Abstract
Adverse childhood experiences have been shown to affect sensitivity to intranasal oxytocin administration, but the neural mechanisms underlying this altered sensitivity are unclear. The aim of the current study was to examine whether hippocampal abnormalities underlie the effects of adversity on the response to oxytocin administration. In a sample of healthy women (N = 54, age M = 19.63), we examined 1) the association between hippocampal volume and experiences of emotional maltreatment and 2) whether hippocampal volume reductions influence the effect of intranasal oxytocin administration on salivary oxytocin levels. There was no association between hippocampal volume and experiences of emotional maltreatment in the current study. However, we found that larger hippocampal volume was related to a stronger increase in salivary oxytocin level after intranasal oxytocin administration. The hippocampus may be a neural substrate underlying individual differences in sensitivity to oxytocin administration.
Description
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue
Keywords
SDG 16 - Peace, Justice and Strong Institutions
Citation
Riem, M M E, Van Ijzendoorn, M H & Bakermans-Kranenburg, M J 2018, 'Hippocampal volume modulates salivary oxytocin level increases after intranasal oxytocin administration', Psychoneuroendocrinology, vol. 101, pp. 182-185. https://doi.org/10.1016/j.psyneuen.2018.11.015
License
info:eu-repo/semantics/openAccess