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Remote blood collection among cancer patients and age- and sex-matched controls for biomarker and genetic analyses using the PROFILES registry
Mols,Floortje van Cappellen-van Maldegem,Sandra Hoedjes,Meeke Horevoorts,Nicole Oerlemans,Simone de Rooij,Belle H. Ezendam,Nicole de Theije,Chiel Hageman,Geja Schoormans,Dounya
Mols,Floortje
van Cappellen-van Maldegem,Sandra
Hoedjes,Meeke
Horevoorts,Nicole
Oerlemans,Simone
de Rooij,Belle H.
Ezendam,Nicole
de Theije,Chiel
Hageman,Geja
Schoormans,Dounya
Abstract
Studies on patient-reported outcomes (PROs) among cancer survivors are increasing but are most often limited to PRO and clinical data. To better understand the underlying biological mechanisms that mediate a decline in health after cancer, several PROFILES-registry studies were enriched with biological data. This paper summarizes lessons learned from collecting blood samples to obtain biomarker data among survivors and controls in large-scale ambulatory cohort studies. These lessons address financial challenges, ethical issues, insurance, legal matters, standardization of assessment, recruitment, communication with participants, lab facilities and protocols, transportation, the need for a biobank, and the value of a normative population. We also describe our experiences with collecting remote blood samples in these studies among cancer patient populations and a study in our normative population to illustrate these issues further.
Description
Date
2026-01-03
Journal Title
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Volume Title
Publisher
Research Projects
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Keywords
Humans, Neoplasms/blood, Registries, Blood Specimen Collection/methods, Male, Female, Patient Reported Outcome Measures, Case-Control Studies, Biomarkers, Tumor/blood, Cohort Studies, Cancer Survivors, SDG 3 - Good Health and Well-being
Citation
Mols, F, van Cappellen-van Maldegem, S, Hoedjes, M, Horevoorts, N, Oerlemans, S, de Rooij, B H, Ezendam, N, de Theije, C, Hageman, G & Schoormans, D 2026, 'Remote blood collection among cancer patients and age- and sex-matched controls for biomarker and genetic analyses using the PROFILES registry', Supportive Care in Cancer, vol. 34, no. 1, 61. https://doi.org/10.1007/s00520-025-10289-z