Metabolomics profiling of Type D Personality traits
Kupper,Nina Li,Ruifang Bot,Mariska Kurilshikov,Alexander Willemsen,Gonneke van Greevenbroek,Marleen J. Schram,Miranda Stehouwer,Coen Fu,Jingyuan Zhernakova,Alexandra
Kupper,Nina
Li,Ruifang
Bot,Mariska
Kurilshikov,Alexander
Willemsen,Gonneke
van Greevenbroek,Marleen J.
Schram,Miranda
Stehouwer,Coen
Fu,Jingyuan
Zhernakova,Alexandra
Abstract
Background: Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, over 230 metabolites or metabolite ratios, predominantly lipids, were investigated for their associations to the Type D personality traits. Methods: Four Dutch cohorts were included, together comprising 10,834 individuals. The Type D personality traits (i.e., NA and SI) were measured by either standard DS14 questionnaire (three cohorts) or ASEBA-based proxy (one cohort). A proton nuclear magnetic resonance metabolomics platform provided 149 absolute measures and 81 derived ratios. For all metabolite measures and ratios, linear regression analyses were performed within cohort, followed by random-effects meta-analyses. A per-measure FDR q-value of Results: SI was significantly associated with the ratio of omega-3 fatty acids to total fatty acids (FAw3.FA%) and free cholesterol to total lipids ratio in very small VLDL (XS.VLDL.FC%). No significant associations were observed between metabolites and NA or Type D. NA did show suggestive replication (p-value<.05) of the previously reported association with depression for five out of 21 metabolites measured on the same metabolomics platform, namely triglycerides in HDL (HDL.TG), serum total triglycerides (serum.TG), VLDL cholesterol (VLDL.C), mean diameter for VLDL particles (VLDL.D) and VLDL triglycerides (VLDL.TG). Conclusions: The ratio of omega-3 fatty acids to total fatty acids was found to associate with social inhibition, which is suggestive of lower omega-3 fatty acid intake. Also, free cholesterol to total lipids ratio in very small VLDL was associated with SI. Our data did not show any metabolite biomarkers that link specifically to Type D. Further studies, including a broader spectrum of metabolites, are warranted to investigate Type D associated biomarkers beyond lipid metabolism
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2022
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Kupper, N, Li, R, Bot, M, Kurilshikov, A, Willemsen, G, van Greevenbroek, M J, Schram, M, Stehouwer, C, Fu, J, Zhernakova, A, Penninx, B W, de Geus, E & Boomsma, D 2022, 'Metabolomics profiling of Type D Personality traits', Psychosomatic Medicine, vol. 84, no. 5, 1476, pp. A111-A111.