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Towards OPtimal TIming and Method for promoting sUstained adherence to lifestyle and body weight recommendations in postMenopausal breast cancer survivors (the OPTIMUM-study): Protocol for a longitudinal mixed-method study
Van Cappellen-van Maldegem,Sandra J. M. Mols,Floortje Horevoorts,Nicole De Kruif,Anja Buffart,Laurien M. Schoormans,Dounya Trompetter,Hester Beijer,Sandra Ezendam,Nicole P. M. De Boer,Michiel
Van Cappellen-van Maldegem,Sandra J. M.
Mols,Floortje
Horevoorts,Nicole
De Kruif,Anja
Buffart,Laurien M.
Schoormans,Dounya
Trompetter,Hester
Beijer,Sandra
Ezendam,Nicole P. M.
De Boer,Michiel
Abstract
Background The majority of postmenopausal breast cancer (PMBC) survivors do not adhere to lifestyle recommendations and have excess body weight. In this group, this is associated with poorer health-related quality of life and an increased risk of type II diabetes mellitus, cardiovascular disease, second primary cancers, cancer recurrences, and mortality. Gaining and maintaining a healthy lifestyle and body composition is therefore important. It is unknown when and how sustained adherence to these recommendations can be promoted optimally in PMBC survivors. Therefore, the OPTIMUM study aims to identify the optimal timing and method for promoting sustained adherence to lifestyle and body weight recommendations in PMBC survivors. Methods The OPTIMUM-study has a mixed-methods design. To assess optimal timing, a longitudinal observational study will be conducted among approximately 1000 PMBC survivors. The primary outcomes are adherence to lifestyle and body weight recommendations, readiness for change, and need for support. Questionnaires will be administered at 4–6 months after cancer diagnosis (wave 1: during treatment and retrospectively before diagnosis), 1 year after diagnosis (wave 2: after completion of initial treatment), and 1.5 years after diagnosis (wave 3: during follow-up). Wave 2 and 3 include blood sampling, and either wearing an accelerometer for 7 days or completing a 3-day online food diary (randomly assigned at hospital level). To assess the optimal method, behavioural determinants of the primary outcomes will be matched with Behavior Change Techniques using the Behaviour Change Technique Taxonomy. Qualitative research methods will be used to explore perceptions, needs and preferences of PMBC survivors (semi-structured interviews, focus groups) and health care providers (Delphi study). Topics include perceptions on optimal timing to promote adherence; facilitators and motivators of, and barriers towards (sustained) adherence to recommendations; and acceptability of the selected methods. Discussion The OPTIMUM study aims to gain scientific knowledge on when and how to promote sustained adherence to lifestyle and body weight recommendations among PBMC survivors. This knowledge can be incorporated into guidelines for tailored promotion in clinical practice to improve health outcomes.
Description
Funding The study is supported with a personal grant from the Dutch Cancer Society (project nr 10960) awarded to MH, and an Investment Subsidy Large (#91101002) of the Netherlands Organization for Scientifc Research (The Hague, The Netherlands).
Date
2021
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Research Projects
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Keywords
Behavior Change Techniques, Biomarkers, Body weight, ELDERLY PASE, HEALTH BEHAVIORS, Lifestyle, METAANALYSIS, MORTALITY, Mixed-method design, Need for support, PHYSICAL-ACTIVITY SCALE, PROFILES registry, Patient reported outcomes, Postmenopausal breast cancer survivors, QUALITY-OF-LIFE, QUESTIONNAIRE, RESEARCH FUND/AMERICAN INSTITUTE, RISK, Stages of change, WAIST CIRCUMFERENCE, SDG 3 - Good Health and Well-being
Citation
Van Cappellen-van Maldegem, S J M, Mols, F, Horevoorts, N, De Kruif, A, Buffart, L M, Schoormans, D, Trompetter, H, Beijer, S, Ezendam, N P M, De Boer, M, Winkels, R, Kampman, E, Schuit, J, Van De Poll-franse, L, Seidell, J C & Hoedjes, M 2021, 'Towards OPtimal TIming and Method for promoting sUstained adherence to lifestyle and body weight recommendations in postMenopausal breast cancer survivors (the OPTIMUM-study) : Protocol for a longitudinal mixed-method study', BMC Women's Health, vol. 21, no. 1, 268. https://doi.org/10.1186/s12905-021-01406-1